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With the United Kingdom’s departure from the European Union, the EU loses arguably its most stalwart supporter of free trade, both with third countries as well as the European single market, which former prime minister Margaret Thatcher did so much to promote. This could have a long-term impact on how the EU does business with its southern partners. It also suggests the direction the UK will take as it seeks to consolidate markets in the Commonwealth – a favourite focus for Leave campaigners – and the wider Global South.